PROS Perspectives – A Webinar Series: "New Revelations in Our Understanding of Vascular Injury Following Multimodality Care" by Dr. John Thomas Lucas Jr.
August 18, 2026
Join Dr. John T. Lucas Jr. for a seminar exploring vasculopathy as it relates to pediatric CNS tumor patients treated with multimodality care, including surgery and radiation therapy.
What You Will Learn:
- The Spectrum of Vasculopathy: Learn to classify vasculopathy into small vessel (e.g., Cerebral Microbleeds, Cavernous Malformations) and large vessel (e.g., Vascular Stenosis, Aneurysm, Atherosclerosis) types. Discover the critical sequelae, including flow dysfunction (Stroke, Moya Moya Syndrome) and brain tissue changes (Lacune, Hemorrhage).
- Risk Factors and Outcomes: Understand why pediatric brain tumor survivors, particularly those receiving Cranial Radiation Therapy (CRT), face a significantly higher relative risk of stroke. Discuss how stroke in childhood cancer survivors is associated with an increased risk of late mortality.
- New Findings on Treatment-Related Injury: Explore new data on the prevalence and cumulative burden of vasculopathy in pediatric CNS tumor survivors. Key findings reveal that areas within the operative bed showed a two-fold increase in the odds of developing vasculopathic changes, and increasing proton RT dose resulted in a 1.7-fold increase in odds. The data also suggests the effect of proton RT dose is primarily seen outside the peri-operative region.
- Clinical Implications: Learn how prediction models and current COG LTFU guidelines manage these complications, and about potential interventions to minimize the risk of this treatment related toxicity.
- Therapeutic Recommendations: Hear why more limited surgical approaches, such as transsphenoidal, are encouraged, as the operative corridor appears to modify the odds of vasculopathic injury.
This seminar provides essential, up-to-date information for clinicians involved in the multimodality care and long-term surveillance of pediatric CNS tumor survivors.
Register [here] - Available only to PROS members
